The Double-Y in one Layer feature makes plotting Before After Graph and Double Y Box Chart much easier in Origin 2023. Note: Line Series is a variation of box chart.

After plotting Line series or box chart, click on the line series or box(es) and use mini toolbar to select Plot on Right Y. Note: For plots already set to plot on right Y, the mini toolbar button will be changed to Plot on Left Y.

The mini toolbar button is also available when choosing plot(s) in Object Manager. (L) or (R) indicator shows in front of plot to indicate current axis assignment.

Before and After

Double Y Box Chart